Dr. Ohhira's Probiotics by Botanica combines ancient Japanese fermentation skills and modern science to create a powerful formula that changes the GI environment to benefit healthful strains and discourage the bad. Twelve carefully selected strains are used in a 3-year fermentation process to maximize health-giving properties and to foster the strongest bacteria. Features: Complete Probiotic System with Live Cultures Original Vegetarian Formula Directions: Take 2 capsules daily or as directed by your health professional. For best results, take 1 capsule with water twice a day on an empty stomach. Temporary reactions such as minor bloating or a mild laxative effect are signs that the beneficial bacteria is detoxifying and improving the gut environment.