MSM originates in the oceans where microscopic plankton release sulfur compounds into seawater, which is quickly converted into dimethyl sulfide or DMS. This sulfur compound escapes into the atmosphere where it reacts with ozone and ultraviolet sunlight to create a product known as MSM. When it rains, the MSM falls to the earth, where it is collected and concentrated in plants. MSM It can be produced in a lab, where it is sometimes combined with other supplements such as glucosamine or chondroitin. It is an organic sulfur-containing nutrient and a naturally-occurring compound in the environment and the human body. The body utilizes and expends MSM on a daily basis. Thatâs because sulfur must be continually replenished for optimal nutrition and health. MSM also helps to build protein in our connective tissues, thus reducing the inflammatory response of the body. The compound is frequently used to help treat joint pain and arthritis.